Follicular Lymphoma International Prognostic Index (FLIPI)

Additional Information

Score Description

The Follicular Lymphoma International Prognostic Index (FLIPI) is a prognostic index for patients with follicular lymphoma. The FLIPI is a modified version of the International prognostic index (IPI) that was originally developed in patients with clinically aggressive non-Hodgkin lymphomas. The FLIPI was devised based on an international study of long-term survival in 4167 patients with follicular lymphoma diagnosed between 1985 and 1992. Patients who were treated received a range of chemotherapies, none including rituximab. However, the FLIPI still retains prognostic relevance in the era of rituximab.

Definition

Stages
Low risk 0–1 points
Intermediate risk 2 points
High risk ≥ 3 points
Points per true condition
Age > 60 yrs. 1
Ann Arbor Stage > II 1
Hb < 120 g/l 1
> 4 involved lymph node areas 1
LDH > reference range 1

Further Reading

Solal-Céligny P et al. Follicular lymphoma international prognostic index. Blood. 2004 Sep 1;104(5):1258-65.