The DIPSS-Score is a dynamic international prognostic scoring system for primary myelofibrosis, which can be applied at any time during the disease course. The score is based on the IPSS, but has been modified to take into account the adverse effect of the acquisition of risk factors over time. The score has been shown to predict the progression of primary myelofibrosis to acute myeloid leukemia. The score was derived from a multivariate analysis of survival of 525 patients with primary myelofibrosis diagnosed between 1980 and 2008.
|Age in years||≤ 65||> 65|
|Presence of constitutional symptoms||No||Yes|
|Hemoglobin [g/l]||≥ 100||< 100|
|White blood cells [G/l]||≤ 25||> 25|
|Peripheral blood blasts [%]||< 1||≥ 1|
|Low risk||0 points|
|Intermediate-1 risk||1–2 points|
|Intermediate-2 risk||3–4 points|
|High risk||5–6 points|
Passamonti F et al. A dynamic prognostic model to predict survival in primary myelofibrosis: a study by the IWG-MRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment). Blood. 2010;115(9):1703-1708.