IPSET-Survival Score (ET)

Additional Information

Score Description

The IPSET survival model derives from multivariate analysis of 867 patients diagnosed with essential thrombocythemia (ET) by WHO criteria. The model was validated in two independent cohorts including 132 WHO-defined ET and 234 Polycythemia vera Study-Group-defined ET patients.

Definition

Risk variables HR, Ci 95% Score 0 Score 1 Score 2
Age [years] 6.5, 3.9–10.7 < 60   > 60
Leukocyte count [G/L] 3.1, 2–4.7 < 11 > 11  
Thrombosis history 2.9, 1.9–4.5 no yes  
Score Risk category Median survival
0 Low risk  
1–2 Intermediate risk 17.5–24.5 years
3–4 High risk 7.1–14.7 years

Further Reading

Passamonti F et al. A prognostic model to predict survival in 867 World Health Organization-defined essential thrombocythemia at diagnosis: a study by the International Working Group on Myelofibrosis Research and Treatment.. Blood 2012; 120 (6):1197-1201.