Additional Information
Score Description
The IPSS -Score is a prognostic scoring system for myelodysplastic syndrome at diagnosis and without treatment; derived from a multivariate analysis of survival and freedom from progression to acute leukemia of 816 patients with de novo myelodysplastic syndrome. Medullary blasts % are taken from definition of WHO classification 2008 (MDS) rather then original publication, since ≥ 20 % blasts are corresponding to acute myeloid leukemia.
Definition
| Points | |||||
|---|---|---|---|---|---|
| Prognostic variables | 0 | 0.5 | 1 | 1.5 | 2 |
| Medullary blasts (%) | 0–4 | 5–10 | – | 11–20 | 21–30 |
| Number of cytopenias | 0–1 | 2–3 | – | – | – |
| Cytogenetic risk group | Low (normal karyotype, 5q-, 20q-, -Y) | Intermediate (all other aberrations) | High (complex karyotype ≥ 3 abnormalities, chromosome 7 anomalies) | ||
| Score | |||||
| Low risk | 0 points | ||||
| Intermediate-I risk | 0.5–1 points | ||||
| Intermediate-II risk | 1.5–2 points | ||||
| High risk | ≥ 2.5 points | ||||