WPSS-Score (MDS)

Additional Information

Score Description

The WPSS-Score is a WHO-classification-based prognostic scoring system for myelodysplastic syndrome, which can be applied – in comparison to the IPSS – at any time during the disease course . While the IPSS was created for use in patients diagnosed with MDS based upon the FAB classification, the WPSS was designed for patients diagnosed with MDS based upon the WHO classification. It was also designed to incorporate information on red cell transfusion need, a characteristic shown to be an independent prognostic factor for patients with MDS.  The score was initially developed using data from 426 patients with de novo MDS between 1992 and 2004 and validated in a second cohort of 739 patients diagnosed with de novo MDS from a another institution between 1982 and 2003.

Definition

  Points
Prognostic variables 0 1 2 3
WHO type RA/RARS/5q- RCMD/RCMD-RS RAEB I RAEB II
Karyotype risk Low (normal karyotype, del(5q), del(20q), -Y) Intermediate (all other aberrations) High (complex karyotype = ≥ 3 anomalies, chromosome 7 anomaly)  
Transfusion requirements None Regularly    
Score
Very low risk 0 points
Low risk 1 points
Intermediate risk 2 points
High risk 3–4 points
Very high risk 5–6 points

Further Reading

Malcovati L et al. Time-dependent prognostic scoring system for predicting survival and leukemic evolution in myelodysplastic syndromes. J Clin Oncol. 2007 Aug 10;25(23):3503-10.