Consensus guidelines on grading of acute graft versus host disease (aGvHD) were published in 1995. Stage of aGvHD is determined separately in the three main target organs (skin, liver, gut); these grades are then used to determine the overall aGvHD grade. The IBMTR and Glucksberg criteria were prospectively validated in 607 patients receiving myeloablative T-cell-replete allogeneic stem cell transplantion between 1996 and 1999. Both systems were predictive of mortality at 100 days and one year post-transplant.
- Glucksberg H, Storb R, Fefer A, Buckner CD, Neiman PE, Clift RA et al. Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors. Transplantation 1974; 18: 295-304
- Rowlings PA, Przepiorka D, Klein JP, Gale RP, Passweg JR, Henslee-Downey PJ et al. IBMTR Severity Index for grading acute graft-versus-host disease: retrospective comparison with Glucksberg grade. Br J Haematol 1997; 97: 855-864